There is definite evidence by various studies performed that cortisol and corticotrophin releasing hormone (CRH) are involved in the etiology of depression. Raised cortisol levels in plasma are found in patients with depression and many studies have also shown CRH levels to be raised in CSF (Burke, 2005). CRH antagonists have been tested in animal models and have shown marked antidepressant activity. Similarly, brain derived neurotrophic factor (BDNF) is also reduced in post mortem reports of depressed individuals showing that it can lead to depression (Karege, 2005). All these genetic findings strongly suggest a biological etiology of depression.
Environmental factors have also been associated with depression. It has been found that stress and difficulties in work or at home can lead to depression. Children who have been sexually abused develop depression in adulthood. Moreover, individuals who suffer a major loss in their lifetime are also at a higher risk of developing depression. Depressed patients are more likely to have a conflicting relationship with their spouse or other family members.
These are excerpts of essays please place order for custom essay paper, term papers, research papers, thesis, dissertation, book reports and case studies.